Intestine specific MTP deficiency with global ACAT 2 gene ablation lowers acute cholesterol absorption with chylomicrons and high density lipoproteins
نویسندگان
چکیده
Correspondence: M. Mahmood Hussain, Department of Cell Biology and Pediatrics, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203 Phone: 718-270-4790; Fax: 718-270-2462; E-mail: [email protected] Or Jahangir Iqbal, Department of Cell Biology and Pediatrics, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203 Phone: 718-270-4790; Fax: 718-270-2462; E-mail: [email protected]
منابع مشابه
Catalysis of ACAT may be completed within the plane of the membrane: a working hypothesis.
Two ACAT sharing protein sequence homology near their C termini have been identified. Both proteins may span the endoplasmic reticulum (ER) membrane several times. There is good evidence implicating the role of ACAT1 in macrophage foam cell formation, and ACAT2 in intestinal cholesterol absorption. On the other hand, the functional roles of ACAT1 and ACAT2 in the VLDL or chylomicron assembly pr...
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